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Post Molar Pregnancy Symptoms

Post Molar Pregnancy Symptoms: A Comprehensive Guide

A molar pregnancy, also known as a gestational trophoblastic disease (GTD), is a rare but serious condition that occurs when the placenta develops abnormally. Instead of forming a healthy placenta, a molar pregnancy results in a mass of grape-like cysts.

After a molar pregnancy, it is important to monitor for post molar pregnancy symptoms, as these can indicate the presence of persistent trophoblastic disease (PTD). PTD is a condition in which trophoblastic tissue, the tissue that forms the placenta, remains in the uterus after a molar pregnancy. PTD can be benign or malignant, and it is important to diagnose and treat it promptly to prevent serious complications.

Symptoms of Post Molar Pregnancy

The symptoms of post molar pregnancy can vary depending on the type of PTD that is present. However, some of the most common symptoms include:

  • Vaginal bleeding
  • Pelvic pain
  • Abdominal pain
  • Nausea and vomiting
  • Fatigue
  • Weight loss
  • Elevated levels of human chorionic gonadotropin (hCG)

Diagnosis of Post Molar Pregnancy

The diagnosis of post molar pregnancy is based on a combination of factors, including:

  • The patient’s history of a molar pregnancy
  • The presence of post molar pregnancy symptoms
  • The results of a physical examination
  • The results of blood tests and imaging studies

Blood tests can be used to measure the levels of hCG in the blood. High levels of hCG can indicate the presence of PTD. Imaging studies, such as ultrasound and MRI, can be used to visualize the uterus and identify any abnormalities.

Treatment of Post Molar Pregnancy

The treatment of post molar pregnancy depends on the type of PTD that is present. Benign PTD can be treated with medication, while malignant PTD may require surgery or chemotherapy.

  • Medication: Methotrexate is the most commonly used medication to treat benign PTD. Methotrexate is an antifolate drug that inhibits the growth of trophoblastic tissue.
  • Surgery: Surgery may be necessary to remove any remaining trophoblastic tissue from the uterus. Surgery is typically performed laparoscopically, which is a minimally invasive procedure.
  • Chemotherapy: Chemotherapy may be necessary to treat malignant PTD. Chemotherapy is a type of medication that kills cancer cells.

Follow-Up Care After Post Molar Pregnancy

After treatment for post molar pregnancy, it is important to have regular follow-up appointments with your doctor. Follow-up appointments will include physical examinations, blood tests, and imaging studies to monitor for any signs of PTD recurrence.

Prognosis for Post Molar Pregnancy

The prognosis for post molar pregnancy depends on the type of PTD that is present. Benign PTD has a good prognosis, with most patients being able to conceive and have a healthy pregnancy after treatment. Malignant PTD has a more guarded prognosis, but the majority of patients can be cured with treatment.

Prevention of Post Molar Pregnancy

There is no known way to prevent molar pregnancy. However, there are some things that you can do to reduce your risk of developing PTD, including:

  • Having regular prenatal care
  • Getting enough folic acid
  • Avoiding smoking and alcohol
  • Managing any underlying medical conditions


Post molar pregnancy symptoms can be a sign of persistent trophoblastic disease. It is important to be aware of these symptoms and to see your doctor if you experience any of them after a molar pregnancy. Early diagnosis and treatment of PTD can help to improve the prognosis and prevent serious complications.

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