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Progesterone Levels Early Pregnancy Prometrium

Progesterone Levels in Early Pregnancy: The Role of Prometrium


Progesterone is a hormone that plays a crucial role in maintaining pregnancy. It is produced by the corpus luteum, a temporary gland that forms on the ovary after ovulation. Progesterone levels rise during the luteal phase of the menstrual cycle and remain elevated if pregnancy occurs.

Progesterone’s Role in Early Pregnancy

Progesterone has several important functions in early pregnancy:

  • Prepares the uterus for implantation: Progesterone thickens the uterine lining (endometrium) and makes it more receptive to implantation of the fertilized egg.
  • Maintains the pregnancy: Progesterone inhibits uterine contractions, preventing premature labor.
  • Supports the development of the placenta: Progesterone promotes the growth and development of the placenta, which provides nutrients and oxygen to the developing fetus.

Progesterone Levels in Early Pregnancy

Progesterone levels typically rise steadily during the first trimester of pregnancy. The following table shows the average progesterone levels at different gestational ages:

Gestational Age Progesterone Level (ng/mL)
4 weeks 5-10
6 weeks 10-20
8 weeks 20-40
10 weeks 40-80
12 weeks 80-120

Prometrium: A Synthetic Progesterone

Prometrium is a synthetic form of progesterone that is used to treat low progesterone levels in early pregnancy. It is typically prescribed in the form of vaginal suppositories or capsules.

When Prometrium is Prescribed

Prometrium may be prescribed in the following situations:

  • Luteal phase defect: A condition where the corpus luteum does not produce enough progesterone during the luteal phase.
  • Threatened miscarriage: When there is a risk of miscarriage due to low progesterone levels.
  • History of recurrent miscarriage: To prevent future miscarriages in women with a history of multiple miscarriages.

Dosage and Administration

The dosage and administration of Prometrium will vary depending on the individual patient and the reason for treatment. It is important to follow the doctor’s instructions carefully.

Side Effects of Prometrium

Prometrium is generally well-tolerated, but some common side effects include:

  • Breast tenderness
  • Bloating
  • Headache
  • Nausea
  • Mood changes

Risks of Prometrium

Prometrium should not be used in women who have:

  • A history of blood clots
  • Liver disease
  • Breast cancer

Monitoring Progesterone Levels

Progesterone levels should be monitored regularly during early pregnancy to ensure that they are within the normal range. This can be done through blood tests or saliva tests.


Progesterone is essential for maintaining a healthy pregnancy. Prometrium is a synthetic progesterone that can be used to treat low progesterone levels in early pregnancy. By understanding the role of progesterone and the use of Prometrium, healthcare providers can help women achieve successful pregnancies.

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